JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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eISSN: 2980-0854
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Original Article
Effect of tyrosine kinase inhibitor and conventional chemotherapy on COVID 19 antibody level in hematological patients
Abstract
Aims: In this study, we aim to discover if there is a difference between COVID 19 antibody level in hematological patients taking conventional chemotherapy and tyrosin kinase inhibitors.
Methods: COVİD 19 IgG levels were measured using the QuantiCOR anti-SARS-CoV-2 IgG ELISA test kit on 74 patients who received chemotherapy and used tyrosine kinase inhibitors in the adult hematology clinic of Turgut Özal Medical Center between May 2019 and January 2022. Age, height, weight, badimeks index of the patients were measured, the doses and durations of vaccine use, the time between the first vaccine and the second vaccine, how long after the first vaccine antibodies were checked, and vaccine-related side effects were recorded. Collected data Statistical analysis was performed using Python 3.9 and IBM SPSS Statistics for Windows version 26.0 (New York; USA).
Results: Antibody levels of the patients were significantly higher in the healthy control group than in the groups that received chemotherapy and tyrosine kinase inhibitors. Antibody levels of female patients in the control group were higher than male patients. Antibody levels of the patient groups receiving chemotherapy and tyrosine kinase inhibitor were not found to differ between the two groups. When the patients receiving B lymphocyte suppressing chemotherapy in the chemotherapy group were compared with the control group, antibody levels were found to be higher in the control group.
Conclusion: COVID 19 vaccination in hematological cancers did not produce adequate antibody response, especially in patients receiving chemotherapy or tyrosine kinase inhibitors.

Keywords : COVID 19 vaccine, tyrosine kinase inhibitor, chemotherapy, anti-SARS-CoV-2 IgG

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Article available in :
Volume 1, Issue 1, 2023
Page : 1-4
https://doi.org/10.51271/JCHOR-0001
Article Information
Received : 20 Ara 2022
Accepted : 24 Şub 2023
Published : 26 Şub 2023
Corresponding Author :

İlhami Berber: Department of Hematology, Turgut Ozal Medical Center, İnonu University, Malatya, Turkiye

İ[email protected]
Citation : Kaya A, Berber İ, Kuku İ, et al. Effect of tyrosine kinase inhibitor and conventional chemotherapy on COVID-19 antibody level in hematological patients. J Curr Hematol Oncol Res. 2023; 1(1): 1-4

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