JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge.

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eISSN: 2980-0854
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Original Article
Real world data of carfilzomib once weekly dosing in patients with relapsed and refractory multiple myeloma: a retrospective single center experience
Abstract
Aims: Relapsed or refractory multiple myeloma (RRMM) remains a therapeutic challenge due to treatment resistance, comorbidities, and limited options after multiple therapy lines. Carfilzomib, a second-generation proteasome inhibitor, has demonstrated efficacy when administered once weekly at 70 mg/m² in combination with dexamethasone (wKd70), offering a convenient and effective alternative to twice-weekly schedules.We conducted a retrospective analysis of 32 RRMM patients treated with wKd70 between 2018 and 2023 at a single referral center.
Methods: Thirty-two RRMM patients were analyzed retrospectively. Patients with RRMM who received at least one course of carfilzomib at a dose of 70 mg/m² (administered on days 1, 8, and 15 of 28-day cycles) in combination with dexamethasone 40 mg/week were included in the study.
Results: The median age was 57.5 years (range: 43–75), and patients had received a median of three prior therapy lines. The overall response rate (ORR) was 62.1% . Median progression-free survival (PFS) was 16 months, and median overall survival (OS) was 51 months . Prior autologous stem cell transplantation was associated with significantly improved PFS and OS. Adverse events were common but mostly mild (grades 1–2) forms.
Conclusion: Our findings support wKd70 as an effective and well-tolerated treatment option for RRMM, even in heavily pretreated patients. The favorable survival outcomes compared to historical trials suggest a role for earlier use of this regimen.

Keywords : RRMM, carfilzomib , dexamethasone, progression free survival, autologous stem cell transplantation

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Article available in :
Volume 4, Issue 3, 2026
Page : 105-109
https://doi.org/10.51271/JCHOR-0091
Article Information
Received : 04 Haz 2026
Accepted : 10 Tem 2026
Published : 08 Ağu 2026
Corresponding Author :

Meral Uluköylü Mengüç: Department of Hematology, Faculty of Medicine, Yeditepe University, İstanbul, Turkiye

[email protected]
Citation : Uluköylü Mengüç M, Şişman İT, Arıkan F, et al. Real world data of carfilzomib once weekly dosing in patients with relapsed and refractory multiple myeloma: single center experience. J Curr Hematol Oncol Res. 2026;4(3):105-109. doi:10.51271/JCHOR-0091

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