JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge.

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Original Article
Association between the CALLY Index and thrombotic risk in polycythemia vera and essential thrombocythemia
Abstract
Aims: Thrombotic complications are the leading cause of morbidity and mortality in patients with polycythemia vera (PV) and essential thrombocythemia (ET). The C-reactive protein–albumin–lymphocyte (CALLY) index has recently emerged as a biomarker reflecting systemic inflammation, nutritional status, and immune function. This study aimed to evaluate the association between the CALLY index and thrombotic risk in patients with PV and ET.
Methods: This retrospective single-center study included 96 adult patients diagnosed with PV or ET between 2015 and 2026. Clinical and laboratory data were obtained from hospital records. Thrombotic events present at diagnosis were confirmed using imaging methods. ROC analysis was performed to assess the predictive performance of the CALLY index, and multivariate logistic regression analysis was used to identify independent predictors of thrombosis.
Results: Among the patients, 77 (80.2%) had PV and 19 (19.8%) had ET. Thrombosis was detected in 27 patients. Patients with thrombosis had significantly lower CALLY scores compared to those without thrombosis (11.8 ± 10.4 vs 19.2 ± 18.9, p = 0.010). Neutrophil counts were significantly higher in the thrombosis group (p = 0.014). Lymphocyte counts were significantly lower in patients with thrombosis compared to those without thrombosis (p = 0.016). ROC analysis demonstrated moderate predictive performance for thrombosis (AUC: 0.670, 95% CI: 0.543–0.788). In multivariate analysis, a low CALLY index (<12) was independently associated with thrombosis (OR: 4.33, 95% CI: 1.54–12.15, p = 0.015).
Conclusion: The lower CALLY index may represent a simple and clinically supportive biomarker for thrombotic risk assessment in PV and ET patients.

Keywords : CALLY, essential thrombocythemia, polycythemia vera, thrombosis

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Ethical Statement

<p>This study was approved by the Non-interventional Clinical Researches Ethics Committee of K&uuml;tahya Health Sciences University (Date: 09.03.2026, Decision No: 2026/03-43).</p>

Informed Consent

<p>This retrospective study used pre-existing anonymized patient data. No additional intervention was performed, and there was no direct patient contact. The study was approved by the Ethics Committee, and the requirement for written informed consent was waived by the ethics committee.</p>

Author Contributions

<p>Concept: CY; Design: CY; Control: C&Ouml;; Resources: C&Ouml;, CY; Materials: CY, C&Ouml;; Data Collection and/or Processing: CY, C&Ouml;; Analysis and/or Interpretation: C&Ouml;, CY; Literature Review: C&Ouml;; Writing The Article: CY; Critical Review: CY, C&Ouml;.</p>

Conflict of Interest

<p>The authors declare no conflicts of interest related to this study.</p>

Financial Disclosure

<p>The authors received no financial support for the conduct or publication of this research.</p>


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Article available in :
Volume 4, Issue 4, 2026
Page : 125-129
https://doi.org/10.51271/JCHOR-0095
Article Information
Received : 04 May 2026
Accepted : 17 Jul 2026
Published : 13 Nov 2026
Corresponding Author :

Cumali Yalçın: Department of Internal Medicine, Faculty of Medicine, University of Health Sciences, Kütahya, Turkiye

[email protected]
Citation : Yalçın C, Özlü C. Association between the CALLY index and thrombotic risk in polycythemia vera and essential thrombocythemia. J Curr Hematol Oncol Res. 2026;4(4):125-129. doi:10.51271/JCHOR-0095

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