JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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eISSN: 2980-0854
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Original Article
Diagnostic white blood cells can be a predictor for mutation existence in myelodisplastic syndromes: the role of next generation sequencing
Abstract
Aims: Myelodisplastic syndromes (MDS) are hematological disorders originating from clonal damage and characterized by inefficient bone marrow activity. The existence of mutations has been shown to play a significant role in risk, treatment response, turnover to acute myeloid leukemia, prognosis, and overall survival. Next-generation sequencing (NGS) is a technique that detects gene mutations and has been the subject of studies for detecting MDS-related mutations.
Methods: We conducted a study on 33 MDS patients during the period of 2021–2023. Patients were analyzed for the existence of mutations with the NGS technique, and the hematological parameters, transfusion need, IPSS, and IPSS-R scores of these patients were recorded.
Results: 15 out of 33 patients (45.5%) were tested for mutations. WBC levels at the diagnosis of patients with type 1 number somatic mutations were higher than in other groups, 7056.25, 2416.67/µL, and 3036.67/µL, respectively (p = 0.048). The ratio of neutrophil and lymphocyte values recorded and NGS positive were higher than those tested negative (1.56 and 3.51, respectively). Patients with the type 1 mutation had higher WBC levels than patients with the type 2 and type 3 mutations, 7056.25/µL, 2416.67/µL, and 3036.67/µL, respectively. 
Conclusion: Genetic mutations are common in MDS patients, and NGS is a useful tool to detect them. Understanding the role of mutations in the matter of risk classification, treatment response, and prognosis is quite important, and larger-scale studies are needed.

Keywords : MDS, myelodisplastic syndromes, NGS, next generation sequencing

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Article available in :
Volume 2, Issue 4, 2024
Page : 87-92
https://doi.org/10.51271/JCHOR-0046
Article Information
Received : 09 Tem 2024
Accepted : 16 Ağu 2024
Published : 14 Kas 2024
Corresponding Author :

Ayşe Günay: Department of Clinical Pharmacy, Konya City Hospital, Konya, Turkiye

[email protected]
Citation : Yılmaz S, Günay A, Cırık S, Baştürk A, Başdemirci M, Balasar Ö. Diagnostic white blood cells can be a predictor for mutation existence in myelodisplastic syndromes: the role of next generation sequencing. J Curr Hematol Oncol Res. 2024;2(4):87-92.

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