JCHOR

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Case Report
A case report of relapsed/refractory primary central nervous system lymphoma
Primary central nervous system lymphoma (PCNSL) is a rare aggressive non-Hodgkin's lymphoma outside the lymph nodes. Currently, high-dose chemotherapy based on methotrexate(MTX) is the standard induction treatment for newly diagnosed PCNSL but effective treatment of relapsed/refractory and elderly PCNSL is still unclear. With the advancement of clinical trials, new drugs and combination therapies such as rituximab and ibrutinib are constantly emerging, increasing the remission rate of resistant and relapsed patients . In this case report, we will try to present a case of relapsed/refractory primary central nervous system lymphoma.


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3. Ferreri TC, Steffanoni FG. How we treat primary central nervoussystem lymphoma. ESMO Open. 2021;6(4):1-5.
4. Pierre Gigilio LBN. Central nervous system cancers. J Natl Compr CancNetw. 2023;(1):37-45.
5. Sophie LL, Caroline H, Carole S. Primary CNS lymphoma at firstrelapse/progression: characteristics, management, and outcome of 256patients from the French LOC network. Neuro Oncol. 2016;18(9):1297-1303. doi:10.1093/neuonc/now033
6. Grommes C, Tang SS, Wolfe J. Phase 1b trial of an ibrutinib-basedcombination therapy in recurrent/refractory CNS lymphoma. Blood.2019;133(5):436-445. doi:10.1182/blood-2018-09-875732
7. Rubenstein JL, Geng H, Fraser EJ. Phase 1 investigation oflenalidomide/rituximab plus outcomes of lenalidomide maintenance inrelapsed CNS lymphoma. Blood Adv. 2018;2(13):1595-1607. doi:10.1182/bloodadvances.2017014845
8. Frigault MJ, Dietrich J, Martinez-Lage M. Tisagenlecleucel CAR T-celltherapy in secondary CNS lymphoma. Blood. 2019;134(11):860-866.doi:10.1182/blood.2019001694.
Volume 2, Issue 3, 2024
Page : 76-78
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