JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge.

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Original Article
Shedding light on allogeneic hematopoietic stem cell transplantation success: exploring the relationship between donor vitamin D and parathormone levels and recipient engraftment and stem cell quantity
Abstract
Aims: The aim of this study is to investigate whether pre-mobilization serum vitamin D and parathormone levels in allogeneic hematopoietic stem cell transplant (allo-HCT) donors have an impact on the collected stem cell quantity and engraftment periods in recipients.
Methods: Data from 35 donors aged 18 and over, who served as donors in allo-HCT performed between 2019 and 2021 at Erciyes University Faculty of Medicine, Bone Marrow Transplantation and Stem Cell Treatment Center, were retrospectively analyzed. Donors with known pathologies related to the parathyroid gland, unrelated and bone marrow-derived stem cell donors were excluded from the study. Donors were grouped as low and high based on serum vitamin D and parathormone levels. The possible relationship between these values and total product CD34+ cell count, neutrophil engraftment time, and platelet engraftment time was assessed.
Results: It was found that recipients of donors with high vitamin D levels had significantly earlier platelet engraftment days compared to donors with low vitamin D levels (p=0.026). In donors with high vitamin D levels, it was observed that the peripheral CD34+ cell count was lower, and the total product CD34+ cell count was higher, although there was no significant relationship (p>0.05). Although recipients of donors with high vitamin D levels had earlier neutrophil engraftment times, no significant relationship was found (p=0.29). A moderate negative correlation was found between platelet engraftment times and vitamin D levels. There was no statistically significant relationship between parathormone levels and stem cell quantities and engraftment times.
Conclusion: Vitamin D deficiency in allo-HCT donors before mobilization was observed to prolong platelet engraftment times in recipients. Therefore, we recommend correcting vitamin D levels in donors before allo-HCT.

Keywords : Allogeneic hematopoietic stem cell transplantation, engraftment, parathormone, vitamin D

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Article available in :
Volume 2, Issue 4, 2024
Page : 79-82
https://doi.org/10.51271/JCHOR-0044
Article Information
Received : 08 Mar 2024
Accepted : 03 Nis 2024
Published : 14 Kas 2024
Corresponding Author :

Dicle Uzun: Department of Internal Medicine, Ürgup State Hospital, Nevşehir, Turkiye

[email protected]
Citation : Uzun D, Keklik M, Eser B. Shedding light on allogeneic hematopoietic stem cell transplantation success: exploring the relationship between donor vitamin D and parathormone levels and recipient engraftment and stem cell quantity. J Curr Hematol Oncol Res. 2024;2(4):79-82.

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