JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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eISSN: 2980-0854
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Original Article
Does early granulocyte colony-stimulating factor administration in autologous peripheral blood stem cell transplantation shorten the duration of hospitalization in patients with multiple myeloma?
Abstract
Aims: Autologous peripheral blood stem cell transplantation (PBSCT), performed with high-dose melphalan support following induction therapy is still the gold standard method of treatment for multipl myeloma (MM)patients suitable for transplantation. It was aimed, with this retrospective study, to investigate the effects of early (1 day after PBSCT) and late (5 days after PBSCT) initiation of granulocyte colony-stimulating factor (G-CSF) support following PBSCT on engraftment time, febrile neutropenia, and length of hospital stay (LOS) in MM patients.
Methods: This study included 70 patients with MM, who underwent PBSCT in Erciyes University. Two groups were administered 5µg/kg filgrastim, subcutaneously, either 1 day or 5 days after PBSCT, until neutrophil engraftment was reached.
Results: Both neutrophil and platelet engraftment occurred in significantly shorter times in the early G-CSF group compared to late G-CSF group; the median times to neutrophil engraftment were 10 (8-13) and 11 (7-15) days, respectively, and the median times to platelet engraftment were 11 (10- 16) and 13 (11- 21) days (p=0.001). Also, the median LOS was also significantly shorter in the early G-CSF group compared to late G-CSF group; 14 (10-22) vs 16 (11- 33) days, respectively (p=0.016). No significant difference was found between the groups in terms of frequency of febrile neutropenia.
Conclusion: The initiation of G-CSF support early, following PBSCT in MM patients, accelerated neutrophil and platelet engraftment and shortened the LOS as compared to the initiation of G-CSF support late, with no significant difference in the frequency of febrile neutropenia.

Keywords : Autologous hematopoietic stem cell transplantation, granulocyte colony-stimulating factor, multiple myeloma

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Article available in :
Volume 2, Issue 2, 2024
Page : 41-46
https://doi.org/10.51271/JCHOR-0035
Article Information
Received : 21 Şub 2024
Accepted : 03 Nis 2024
Published : 14 May 2024
Corresponding Author :

Serhat Çelik: Department of Hematology, Yenimahalle Training and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkiye

[email protected]
Citation : Keklik M, Topal L, Çelik S, Kaynar L. Does early granulocyte colony-stimulating factor administration in autologous peripheral blood stem cell transplantation shorten the duration of hospitalization in patients with multiple myeloma?.J Curr Hematol Oncol Res. 2024;2(2):41-46.

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