JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

ISSN: Active
eISSN: 2980-0854
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Causes of acquired isolated neutropenia in adulthood: a single center study
Abstract
Aims: Neutropenia, associated with several hereditary and acquired causes, is detected in a significant portion of patients presenting to the hematology outpatient clinic today. We conducted this study since we failed to find any Turkish publication on acquired isolated neutropenia in adults.
Methods: This retrospective study examined data belonging to patients aged 18 years and older who applied to the adult hematology outpatient clinic whose absolute neutrophil count (ANC) was below the normal reference values (? 1.5 x 109/L).
Results: 103 adult patients, 93 women and 10 men, were included in the study. Our study detected the cause of acquired isolated neutropenia as chronic idiopathic neutropenia (CINA) in 39.8% (n=41) of patients, autoimmune diseases in 18.4% (n=19), drugs in 14.6% (n=15), folate deficiency in 13.6% (n=14), infection in 9.7% (n=10), and hematological malignancy in 2.9% (n=3) and cyclic neutropenia in 1% (n=1). 92 patients (89.3%) were found to display mild neutropenia while 9 (8.7%) displayed moderate neutropenia and 2 (2%) displayed severe neutropenia. Interestingly, folate deficiency was detected in 6 of 9 (66.7%) moderately neutropenic patients.
Conclusion: In our study, CINA was determined as the most common cause of acquired isolated neutropenia in adults, while autoimmune neutropenia was the second most common. In addition, the detection of folate deficiency in 6 of 9 patients (66.7%) with moderate neutropenia and the fact that these patients were in the advanced age group [mean 68 (range 62-81)] was a major finding of the study.

Keywords : Adult neutropenia, acquired isolated neutropenia, chronic idiopathic neutropenia, folate deficiency, autoimmune neutropenia

Download Article


1. Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is anormal absolute neutrophil count? J Lab Clin Med. 1999;133(1):15-22.doi:10.1053/lc.1999.v133.a94931
2. Lee N, Lee BC (2020) Incidence of Severe Chronic Neutropenia in SouthKorea and Related Clinical Manifestations: a national health ıInsurancedatabase study. Medicina. 2020;56(6):262.
3. Dale DC, Bolyard AA, Schwinzer BG, et al. The severe chronicneutropenia ınternational registry:10-year follow-up report. SupportCancer Ther. 2006;3(4):220-231
4. Gibson C, Berliner. How we evaluate and treat neutropenia in adults.Blood. 2014;124(8):1251-1258.
5. Akhtari M, Curtis B, Waller EK.Autoimmune neutropenia in adults.Autoimmun Rev. 2009;9(1):62-66.
6. Malik D, Kuriakose P, Philip J, Hejab A, Horbal A, Mendiratta V.Evaluating the clinical utility of testing for autoimmune disorders in thesetting of leukopenia/neutropenia in an ambulatory hematology clinic.Blood. 2017;(130):1000.
7. Palmblad J, Siersma V, Lind B, Bjerrum OW, Hasselbalch H, AndersenCL.Age-related prevalence and clinical significance of neutropeniaisolated or combined with other cytopenias: real world data from 373 820primary care individuals. Am J Hematol. 2020;95(5):521-528.
8. Newburger PE, Dale DC. Evaluation and management of patients withisolated neutropenia. Semin Hematol. 2013;50(3):198-206.
9. Dale, Davıd C,Welte K. Neutropenia and neutrophilia.Williamshematology. 2001;(8):939-950.
10. Palmblad J, Dufour C, Papadaki HA. How we diagnose neutropenia inthe adult and elderly patient. Haematologica. 2014;99(7):1130-1133.doi:10.3324/haematol.2014.110288
11. Frater JL. How I investigate neutropenia. Int J Lab Hematol.2020;42(1):121-132. doi:10.1111/ijlh.13210
12. Lima CS, Paula EV, Takahashi T, Saad ST, Lorand-Metze I, CostaFF. Causes of incidental neutropenia in adulthood. Ann Hematol.2006;85(10):705-709. doi:10.1007/s00277-006-0150-0
13. Papadaki HA, Psyllaki M, Eliopoulos DG, Tsiroyianni A, EliopoulosGD. Increased frequency and specific reactivity of serum antinuclearantibodies in patients with nonimmune chronic idiopathic neutropeniaof adults. Acta haematologica. 2001;105(1):13-20. doi:10.1159/000046527
14. Yilmaz D, Ritchey AK. Severe neutropenia in children: a singleinstitutional experience. J Pediatr Hematol Oncol. 2007;29(8):513-518.doi:10.1097/MPH.0b013e3180f61b26
15. Dale DC, Cottle TE, Fier CJ,et al.Severe chronic neutropenia: treatmentand follow-up of patients in the Severe Chronic Neutropenia InternationalRegistry. Am J Hematol. 2003;72(2):82-93.
16. Kyle RA, Linman JW. Chronic idiopathic neutropenia. a newlyrecognized entity? N Engl J Med. 1968;279(19):1015-1019. doi:10.1056/nejm196811072791902
17. Kyle RA. Natural history of chronic idiopathic neutropenia. N Engl J Med.1980;302 (16):908-909. doi:10.1056/nejm198004173021608
18. Papadaki HA, Xylouri I, Coulocheri S, Kalmanti M, Kafatos A, EliopoulosGD.Prevalence of chronic idiopathic neutropenia of adults among anapparently healthy population living on the island of Crete. Ann Hematol.1999;78(7):293-297. doi:10.1007/s002770050518
19. Newman KA, Akhtari M. Management of autoimmune neutropenia inFelty’s syndrome and systemic lupus erythematosus. Autoimmun Rev.2011;10(7):432-437. doi:10.1016/j.autrev.2011.01.006
20. Andrès E, Mourot-Cottet R. Non-chemotherapy drug-inducedneutropenia - an update. Expert Opin Drug Saf. 2017;16(11):1235-1242.
21. Andrès E, Mourot-Cottet R, Maloisel F, et al. Idiosyncratic drug-inducedneutropenia & agranulocytosis. Qjm. 2017;110(5):299-305. doi:10.1093/qjmed/hcw220
22. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC.Prevalence of anemia in persons 65 years and older in the United States:evidence for a high rate of unexplained anemia. Blood. 2004;104(8):2263-2268
23. den Elzen WP, Westendorp RG, Frölich M, de Ruijter W, Assendelft WJ,Gussekloo J. Vitamin B12 and folate and the risk of anemia in old age: theLeiden 85-Plus Study. Arch Intern Med. 2008;168(20):2238-2244.
24. Andersen CL, Tesfa D, Siersma VD, et al. Prevalence and clinicalsignificance of neutropenia discovered in routine complete bloodcell counts: a longitudinal study. J Intern Med. 2016;279(6):566-575.doi:10.1111/joim.12467
25. Angelino G, Caruso R, D’Argenio P, et al. Etiology, clinical outcome, andlaboratory features in children with neutropenia: analysis of 104 cases.Pediatr Allergy Immunol. 2014;25(3):283-289. doi:10.1111/pai.12177
26. Wan C, Yu HH, Lu MY, Lee JH, Wang LC, Lin YT, Yang YH, Chiang BL.Clinical manifestations and outcomes of pediatric chronic neutropenia. JFormos Med Assoc. 2012; 111(4):220-227. doi:10.1016/j.jfma.2010.12.003
27. Dale DC, Hammond WPt. Cyclic neutropenia: a clinical review. BloodRev. 1988;2(3):178-185. doi:10.1016/0268-960x(88)90023-9
Article available in :
Volume 2, Issue 3, 2024
Page : 59-62
https://doi.org/10.51271/JCHOR-0039
Article Information
Received : 20 Şub 2024
Accepted : 20 Mar 2024
Published : 01 Ağu 2024
Corresponding Author :

Serhat Çelik: Department of Hematology, Yenimahalle Training and Research Hospital, Yıldırım Beyazıt University, Ankara, Turkiye

[email protected]
Citation : Keklik M, Mert Yüce M, Akyol G, Mandacı Şanlı N, Çelik S, Eser B. Causes of acquired isolated neutropenia in adulthood: a single center study.J Curr Hematol Oncol Res. 2024;2(3):59-62.

Read: 175
Cited: 0
Download : 90
_Footer