JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
The investigation of janus kinase 2 and calreticulin mutations in patients with essential thrombocytosis
Abstract
Aims: The aims of this study were to investigate the frequency of Janus Kinase 2 (JAK2) and calreticulin (CALR) mutations in patients with essential thrombocytosis (ET) and primary myelofibrosis (PMF) and to compare the data of each group with JAK2 and CALR mutations (+) and (-).
Methods: The research group consisted of 80 patients with chronic myeloproliferative disease (CMPD) followed in Gazi University Hospital of Medical Faculty, Hematology Clinic.
Results: Of the patients included in the study, 66.2% had ET and 33.8% had PMF. JAK2 mutation (+) was detected in 60% and CALR mutation (+) was found in 22.5% of the patients. JAK2 mutation (+) was detected in 60.4% of patients with ET and 59.3% of patients with PMF. In JAK2 (-) patients, CALR was detected as (+) in 11 patients (52.4%) with ET and 7 patients (63.6%) with PMF.
Conclusion: Studies in the literature have shown that the incidence of CALR mutations in patients with CMPD is between 28% and 80% and that the mutation is mostly seen in patients with ET. As a result of our study, it was concluded that the laboratory findings of patients with CALR mutations (+) were similar to those in the literature and were more common in women and ET patients.

Keywords : Essential thrombocytosis, primary myelofibrosis, JAK2, calreticulin

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Article available in :
Volume 2, Issue 3, 2024
Page : 54-58
https://doi.org/10.51271/JCHOR-0038
Article Information
Received : 12 Şub 2024
Accepted : 04 Mar 2024
Published : 01 Ağu 2024
Corresponding Author :

Servihan Ünal: Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Department of Hematology, Ankara, Türkiye

[email protected]
Citation : Ünal S, Yağcı AM. The investigation of janus kinase 2 and calreticulin mutations in patients with essential thrombocytosis. J Curr Hematol Oncol Res. 2024;2(3):54-58.

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