JCHOR
Journal of Current Hematology & Oncology Research

The Journal of Current Hematology & Oncology Research regularly publishes internationally qualified research in hematology and oncology within the current scholarly knowledge.

ISSN: Active
eISSN: 2980-0854
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Case Report
A rare case of acute basophilic leukemia
Abstract
Acute basophilic leukemia is an extremely rare form of acute myeloid leukemia and diagnosis is based on morphological, cytochemical and ultrastructural analyses of basophils and blastic cells. It is usually characterized by a very rapid clinical course, symptoms of hyperhistaminemia and resistance to therapy. A 73 year-old male presented with itching, thrombocytopenia and leukocytosis. There was no hepatosplenomegaly. In the flow cytometry evaluation of peripheral blood, CD123 positive myeloid blasts were detected at the rate of 60%. Also, CD13 and CD33 were positive, while CD34, CD117, HLA DR and myeloperoxidase (MPO) were negative. These findings were considered as consistent with ABL. Following, the diagnosis of ABL was confirmed by bone marrow evaluation including cytomorphological and immunohistochemical studies. On the other hand, cytogenetical analyses of bone marrow showed the presence of the Philadelphia chromosome.The patient received one cycle of a chemotherapy regimen including cytarabine and idarubicin with imatinib support, but he died on the 10th hospital day. Considering that ABL behaves in a very malignant fashion, and a more aggressive treatment approach is necessary for patients with this specific subtype of AML.

Keywords : Acute basophilic leukemia, CD123 antigen, flow cytometry

Download Article


1. Carruale A, Muntone G, Rojas R, Bonfigli S, Virdis P, Longu F, et al.Acute basophilic leukemia with U2AF1 mutation. Blood Cells Mol Dis.2019;76:63-5.
2. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, etal. The 2016 revision to the World Health Organization classification ofmyeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-405.
3. Valent P, Sotlar K, Blatt K, Hartmann K, Reiter A, Sadovnik I, et al.Proposed diagnostic criteria and classification of basophilic leukemiasand related disorders. Leukemia. 2017;31(4):788-97.
4. Keung Y-K, Beaty M, Powell BL, Molnar I, Buss D, Pettenati M.Philadelphia chromosome positive myelodysplastic syndrome andacute myeloid leukemia—retrospective study and review of literature.Leukemia research. 2004;28(6):579-586.
5. Han J-Y, Theil KS. The Philadelphia chromosome as a secondaryabnormality in inv (3)(q21q26) acute myeloid leukemia at diagnosis:confirmation of p190 BCR-ABL mRNA by real-time quantitativepolymerase chain reaction. Cancer genetics and cytogenetics.2006;165(1):70-74.
6. Shvidel L, Shaft D, Stark B, Shtalrid M, Berrebi A, Resnitzky P. Acutebasophilic leukaemia: eight unsuspected new cases diagnosed byelectron microscopy. British journal of haematology. 2003;120(5):774-781.
7. Pidala J, Pinilla-Ibarz J, Cualing HD. A case of acute basophilic leukemiaarising from chronic myelogenous leukemia with development of t (7; 8)(q32; q13). Cancer genetics and cytogenetics. 2008;182(1):46-49.
Article available in :
Volume 1, Issue 3, 2023
Page : 73-75
https://doi.org/10.51271/JCHOR-0016
Article Information
Received : 23 Haz 2023
Accepted : 11 Tem 2023
Published : 30 Ağu 2023
Corresponding Author :

Serhat Çelik: Division of Hematology, Department of Internal Medicine, Faculty of Medicine Ankara University

[email protected]
Citation : Çelik S, Keklik M, Kontaş O, Koker MY, Kaynar L. A rare case of acute basophilic leukemia. J Curr Hematol Oncol Res. 2023;1(3):73-75.

Read: -2073
Download : 4935
Cited: 0
_Footer